Combination of non-vitamin K antagonist oral anticoagulants and antiepileptic drugs     
Yazarlar (3)
Semiha Gülsüm Kurt
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Orhan SÜMBÜL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Dürdane AKSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Makale Türü Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri)
Makale Alt Türü SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale
Dergi Adı EUROPEAN HEART JOURNAL
Dergi ISSN 0195-668X Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 05-2019
Cilt No 40
Sayı 19
Sayfalar 1572 / 1572
DOI Numarası 10.1093/eurheartj/ehz091
Makale Linki https://academic.oup.com/eurheartj/article/40/19/1572/5369797
Özet
We read with great interest the article by Steffel et al. 1 as neurology specialists. The authors performed a very useful and comprehensive guide. However, in table 5 carbamazepine, levetiracetam, phenobarbital, phenytoin, topiramate, and valproic acid have been marked with hatched dark brown, and have been reported to be contraindicated due to their effects on plasma levels of NOACs. It has been emphasized that ‘the hatched colour coding indicates no clinical or PK data available, and recommendations are based on the respective NOAC SmPC, where available or expert opinion’. 1 As mentioned in the articles 2, 3 that the authors used as reference for the table 5, the clinical relevance of these drug interactions is largely unknown since mainly data from in vitro and animal studies are available, and there are only sporadic case reports in humans. Since there are indications that substrate recognition and …
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