Super-Enhancer-Driven RAE1 Shows Higher Protein Levels in Tumor Compared to Adjacent Nonmalignant Stroma in High-Grade Serous Ovarian Cancer Patients
Yazarlar (2)
Dr. Öğr. Üyesi Çağlar BERKEL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ercan ÇAÇAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Reproductive Sciences |
| Dergi ISSN | 1933-7191 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2023 |
| Cilt No | 30 |
| Sayı | 8 |
| Sayfalar | 2397 / 2400 |
| DOI Numarası | 10.1007/s43032-023-01199-8 |
| Makale Linki | http://dx.doi.org/10.1007/s43032-023-01199-8 |
| Özet |
| To the Editor, Ovarian cancer is the most lethal of gynecological malignancies, and cellular processes regulating ovarian cancer initiation, progression, and resistance to therapy are not still completely uncovered [1]. Cancer cells can rewire or hijack regulatory DNA elements, including transcriptional enhancers, to activate genes that promote tumor initiation, metastasis, and chemoresistance, and this is particularly true for cancer types that have little or no known driver mutations within protein-coding genes, such as ovarian cancer [2]. Enhancers are non-coding regulatory DNA sequences that contain information for the binding of transcription factors and interact spatially with their target genes to orchestrate spatiotemporal patterns of gene expression, ultimately resulting in the enhanced transcription (upregulation) of the associated genes [3]. Large clusters of enhancers in close genomic proximity that have … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 1 |
| SCOPUS | 1 |
| Google Scholar | 1 |