Sodium selenite and vitamin E in preventing mercuric chloride induced renal toxicity in rats
Yazarlar (4)
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Dr. Öğr. Üyesi Filiz DEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Food and Chemical Toxicology |
| Dergi ISSN | 0278-6915 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2014 |
| Cilt No | 70 |
| Sayı | 1 |
| Sayfalar | 185 / 190 |
| DOI Numarası | 10.1016/j.fct.2014.05.010 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0278691514002440 |
| Özet |
| This study aims to investigate improving effects of sodium selenite and/or vitamin E on mercuric chloride-induced kidney impairments in rats. Wistar male rats were exposed either to sodium selenite (0.25. mg/kg. day), vitamin E (100. mg/kg. day), sodium selenite. +. vitamin E, mercuric chloride (1. mg/kg. day), sodium selenite. +. mercuric chloride, vitamin E. +. mercuric chloride and sodium selenite. +. vitamin E. +. mercuric chloride for 4. weeks. Mercuric chloride exposure resulted in an increase in the uric acid, creatinine, blood urea nitrogen and malondialdehyde (MDA) levels and a decrease in the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. Histopathological changes were detected in kidney tissues in mercuric chloride-treated groups. A significant decrease in the uric acid, creatinine, blood urea nitrogen and MDA levels and a significant increase in the SOD, CAT and GPx activities were observed in the supplementation of sodium selenite and/or vitamin E to mercuric chloride-treated groups. Conclusively, sodium selenite, vitamin E and vitamin E. +. sodium selenite significantly reduce mercuric chloride induced nephrotoxicity in rats, but not protect completely. © 2014 Elsevier Ltd. |
| Anahtar Kelimeler |
| Histopathology | Kidney toxicity | Mercuric chloride | Oxidative stress | Sodium selenite | Vitamin E |
Science Direct
Sodium selenite and vitamin E in preventing mercuric chloride induced renal toxicity in rats
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 37 |
| SCOPUS | 37 |