Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure
Yazarlar (7)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bartın Üniversitesi, Türkiye
Yozgat Bozok Üniversitesi, Türkiye
Doç. Dr. Hüseyin AKBAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Yıldız Teknik Üniversitesi, Türkiye
Kütahya Dumlupınar Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Scientific Reports |
| Dergi ISSN | 2045-2322 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2020 |
| Cilt No | 10 |
| Sayı | 1 |
| Sayfalar | 12472 / 0 |
| DOI Numarası | 10.1038/s41598-020-69416-x |
| Makale Linki | https://doi.org/10.1038/s41598-020-69416-x |
| Özet |
| Four new dicyanoargentate(I)-based complexes 1–4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl) -ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI–MS for 1–3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten)2]2+ cations and [Ag(CN)2]− anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1–4) and anticancer effects (2–4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |
| SCOPUS | 12 |