A potentiometric biosensor for the determination of valproic acid: Human blood-based study of an anti-epileptic drug
Yazarlar (3)
Doç. Dr. Oğuz ÖZBEK
Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Prof. Dr. Ömer IŞILDAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yıldız Teknik Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biochemical Engineering Journal |
| Dergi ISSN | 1369-703X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 176 |
| Sayı | 1 |
| Sayfalar | 108181 / 0 |
| DOI Numarası | 10.1016/j.bej.2021.108181 |
| Makale Linki | http://dx.doi.org/10.1016/j.bej.2021.108181 |
| Özet |
| A potentiometric poly (vinyl chloride) (PVC) membrane–based biosensor has been developed for the determination of the anti–epileptic drug valproic acid in human blood samples. The valproate–selective biosensor worked well over a wide concentration range from 1.0 × 10-6 to 1.0 × 10-1 mol L-1 with Nernstian slope of 59.0 ± 3.6 mV/decade. The biosensor exhibited a lower detection limit of 9.75 × 10-7 mol L-1. The developed valproate–selective biosensor showed very good selectivity for anti–epileptic drugs such as carbamazepine, levetiracetam and phenytoin, and for some ions present in human blood. The biosensor displayed a fast response time of less than 10 s, good reusability and stability, and operated in the wide pH range of 4.0–11.0. The morphology of the developed PVC membrane biosensor was analyzed by scanning electron microscopy. Finally, the determination of valproic acid in human blood samples was carried out using the standard addition method with very high recoveries. |
| Anahtar Kelimeler |
| Anti–epileptic | Biosensor | Epilepsy | Potentiometry | Valproic acid |
Science Direct
A potentiometric biosensor for the determination of valproic acid: Human blood-based study of an anti-epileptic drug
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 28 |
| SCOPUS | 41 |
| Google Scholar | 47 |