Synthesis and bioactivity studies on new 4-(3-(4- Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2- c]pyrazol-2-yl) benzenesulfonamides
Yazarlar (6)
Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehtap TUĞRAK SAKARYA
Atatürk Üniversitesi, Türkiye
Meikai University, Japonya
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Università Degli Studi Di Firenze, İtalya
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2016 |
| Cilt No | 31 |
| Sayı | 6 |
| Sayfalar | 1619 / 1624 |
| DOI Numarası | 10.3109/14756366.2016.1160077 |
| Özet |
| A series of new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides (7–12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1–6) and 4-hydrazinobenzenesulfonamide. The substituted benzaldehydes from which the key intermediate was prepared by introducing 2- or 4-substituents such as fluorine, hydroxy, methoxy, or the 3,4,5-trimethoxy moieties. The compounds were tested for their cytotoxicity, tumor-specificity and potential as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The 3,4,5-trimethoxy and the 4-hydroxy derivatives showed interesting cytotoxic activities, which may be crucial for further anti-tumor activity studies, whereas some of these sulfonamides strongly inhibited both human (h) cytosolic isoforms hCA I and II. |
| Anahtar Kelimeler |
| Benzenesulfonamide | carbonic anhydrase/enzyme inhibition | cytotoxicity | indane | pyrazole | tumor selectivity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 138 |
| Google Scholar | 146 |
| Google Scholar | 148 |