Ursodeoxycholic acid protects neonatal rats from necrotizing enterocolitis: A biochemical, histopathological, and immunohistochemical study
Yazarlar (4)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Prof. Dr. Ali GÜL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kapadokya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Maternal-Fetal Neonatal Medicine |
| Dergi ISSN | 1476-7058 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2021 |
| Cilt No | 34 |
| Sayı | 22 |
| Sayfalar | 3761 / 3767 |
| DOI Numarası | 10.1080/14767058.2020.1818210 |
| Makale Linki | https://www.tandfonline.com/doi/pdf/10.1080/14767058.2020.1818210 |
| Özet |
| The pathophysiology of necrotizing enterocolitis (NEC) includes the massive production of endogenous cytokines with exaggerated activation of inflammatory pathways. Ursodeoxycholic acid (UDCA) has been used as an anti-inflammatory, antioxidant, and anti-apoptotic agent. We investigated the possible protective effects of UDCA in a neonatal rat pup model of NEC. We randomly divided rat pups into three groups: a control group, a non-treated NEC group, and a UDCA-treated NEC group. We induced NEC by feeding formula enterally and hypoxia/reoxygenation. Intestinal samples were collected for histopathological and immunohistochemical evaluation. Blood samples were taken for biochemical analyses. UDCA significantly reduced the extents of terminal ileal and jejunal injuries compared to the NEC group ( < .01), reduced Bax and caspase-3 immunoreactivities (both < .01), and lowered serum levels of platelet-activating factor and intestinal fatty acid-binding protein ( < .01, = .023, respectively). In a rat model of NEC, UDCA protects against adverse intestinal histological, immunohistochemical, and biochemical changes. UDCA significantly reduces the effects of NEC on the rat pup intestine. |
| Anahtar Kelimeler |
| Necrotizing enterocolitis | ursodeoxycholic acid | PAF | IFABP |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 5 |
| Google Scholar | 7 |