Etomidate alleviates ovarian ischemia-reperfusion injury in rats
Yazarlar (8)
Dr. Öğr. Üyesi Vildan KÖLÜKÇÜ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mehtap GÜRLER BALTA
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hakan TAPAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Tuğba KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mardin Artuklu University, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Ulusal Travma Ve Acil Cerrahi Dergisi |
| Dergi ISSN | 1306-696X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2024 |
| Cilt No | 30 |
| Sayı | 6 |
| Sayfalar | 375 / 381 |
| DOI Numarası | 10.14744/tjtes.2024.27388 |
| Makale Linki | http://dx.doi.org/10.14744/tjtes.2024.27388 |
| Özet |
| BACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury.METHODS: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activityRESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p= 0.005, p= 0.016, and p< 0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p< 0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased in Group 3 compared to Group 2 (p= 0.031 and p= 0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p< 0.001, p< 0.001, p< 0.001, and p= 0.001, respectively).CONCLUSION: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histopathological and biochemical outcomes. |
| Anahtar Kelimeler |
| Etomidate | ovarian torsion and detorsion | ischemia-reperfusion injury | oxidative stress. |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 6 |
| TRDizin | 1 |
| Google Scholar | 7 |