Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients
Yazarlar (4)
Doç. Dr. Muzaffer KATAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
A. F. Ozugurlu
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
H. Ozyurt
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
I. Benli
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Genetics and Molecular Research (Q4) | ||
| Dergi ISSN | 1676-5680 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2014 |
| Cilt / Sayı / Sayfa | 13 / 1 / 1030–1037 | DOI | 10.4238/2014.February.20.4 |
| Makale Linki | https://www.geneticsmr.com/articles/2901 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1* 0501, DQB1* 0201, and DRB1* 04 that are frequently reported for CD. SOD and GSH-Px polymorphisms were investigated by realtime quantitative polymerase chain reaction in 265 cases. Of the 117 cases that had at least one of DQA1* 0501, DQB1* 0201, or DRB1* 04, 98 (83.75%) also had SOD enzyme polymorphisms and 68 (58.12%) also had GSH-Px polymorphisms. In conclusion, although the etiology of CD is not yet entirely clear, many mechanisms have been suggested. This study supports the notion that SOD and GSH-Px polymorphisms are involved in CD development, even though our findings were not |
| Anahtar Kelimeler |
| Antioxidant | Inflammation | Mutation | Oxidative stress | Polymorphism | Small bowel |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 12 |
| Google Scholar | 22 |