Protective effects of dexmedetomidine on ischaemia reperfusion injury in an experimental rat model of priapism
Yazarlar (8)
Engin Kölükçü Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bekir S. Parlaktaş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Vildan Kölükçü Tokat State Hospital, Türkiye
Fatih Firat Tokat State Hospital, Türkiye
Faik A. Deresoy Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yunus Emre Kuyucu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Velid Unsal Mardin Artuklu University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Andrologia (Q3) | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2021 |
| Cilt / Sayı / Sayfa | 53 / 3 / 13985– | DOI | 10.1111/and.13985 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1111/and.13985 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| The study aimed to investigate the effects of dexmedetomidine against ischaemia‐reperfusion injury occurring after priapism in a model of induced‐priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia‐reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro‐inflammatory cytokines including interleukin‐1 beta (IL‐1 Beta), interleukin‐6 (IL‐6), and tumour necrosis factor‐alpha (TNF‐alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was … |
| Anahtar Kelimeler |
| dexmedetomidine | ischaemia reperfusion injury | priapism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 7 |
| Google Scholar | 12 |