The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats
Yazarlar (5)
Tekirdağ Namık Kemal Üniversitesi, Türkiye
Ankara Yildirim Beyazit University, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Human and Experimental Toxicology |
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2014 |
| Cilt No | 33 |
| Sayı | 10 |
| Sayfalar | 1008 / 1016 |
| DOI Numarası | 10.1177/0960327113520017 |
| Makale Linki | http://journals.sagepub.com/doi/10.1177/0960327113520017 |
| Özet |
| Endothelin-1 has been shown to increase neuronal activity and glutaminergic synaptic transmission by endothelin-A receptors (ETAR) in the nucleus tractus solitarius neurons that play an important role in epileptic seizures. Therefore, BQ-123 as an ETAR antagonist might attenuate neuronal excitability and glutaminergic synaptic transmission. The main purpose of the present study is to investigate the protective effect of acute BQ-123 treatment against pentylenetetrazole (PTZ)-induced tonic–clonic seizures. Wistar albino rats were divided into three groups: control, PTZ, and PTZ + BQ-123 groups. BQ-123 (3 mg/kg, intravenously) was administered for 15 min before injecting with PTZ (50 mg/kg, intraperitoneally). We determined a delay resulting from BQ-123 in “duration of the seizure onset.” “Number of rats with major seizure” also decreased according to scoring with video camera in PTZ + BQ-123 group. In BQ … |
| Anahtar Kelimeler |
| BQ-123 | endothelin receptor antagonist | Pentylenetetrazole | seizure |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 10 |
| Google Scholar | 12 |