Synthesis of (E)-7-arylidene-5-(hydroxy(aryl)methyl)bicyclo[3.2.0] heptan-6-one derivatives as anti-cancer agents
Yazarlar (7)
Prof. Dr. Mustafa CEYLAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bahar Zorlu
Tokat Gaziosmanpaşa Üniversitesi
Tokat Gaziosmanpaşa Üniversitesi
Prof. Dr. Ayşe Şahin Yağlıoğlu Türkiye
Arş. Gör. Nuray Üremiş Türkiye
Prof. Dr. Meliha Burcu GÜRDERE Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Meryem Keçeci Sarıkaya
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Yakup BUDAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Diğer hakemli uluslarası dergilerde yayınlanan tam makale)
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| Dergi Adı | Journal of New Results in Science | ||
| Dergi ISSN | 1304-7981 | ||
| Dergi Tarandığı Indeksler | worldCad | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 12 / 12 / 149–156 | DOI | 10.54187/jnrs.1366848 |
| Makale Linki | http://dx.doi.org/10.54187/jnrs.1366848 | ||
| UAK Araştırma Alanları |
Organik Kimya
Çevre Kimyası
Polimer Bilimi
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| Özet |
| 7,7-Dichlorobicyclo [3.2.0]heptan-6-one was prepared by adding dichloroketene to cyclopentene. Reduction of 7,7-dichlorobicyclo[3.2.0]heptan-6-one with Zn in acetic acid afforded the bicyclo[3.2.0]heptan-6-one. (E)-7-Arylidene-5-(hydroxy(aryl)methyl)bicyclo [3.2.0]heptan-6-ones were synthesized by addition of related benzaldehydes to bicyclo[3.2.0]heptan-6-one. The anti-proliferative activities of synthesized compounds were elucidated against rat brain tumor (C6) and human cervical carcinoma cells (HeLa) cell lines. The most active compound was chloro derivative against C6 cell lines with IC50 = 2.45 μM value (5-FU, IC50 = 14.82 μM). Moreover, the most active compound was methyl derivative against HeLa cell lines with IC50 = 26.30 μM (5-FU, IC50 = 29.30 μM). |
| Anahtar Kelimeler |
| 𝛼 𝛽-Unsaturated ketones | Anti-proliferative activity | C6 | HeLa | 5-Fu |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 4 |