Potassium carbonate mediated one pot synthesis and antimicrobial activities of 2 alkoxy 4 aryl 5H indeno 1 2 b pyridine 3 carbonitriles
Yazarlar (5)
Erzincan Üniversitesi, Türkiye
Prof. Dr. Meliha Burcu GÜRDERE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Yakup BUDAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Organic Communications |
| Dergi ISSN | 1307-6175 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2016 |
| Cilt No | 9 |
| Sayı | 4 |
| Sayfalar | 125 / 132 |
| Özet |
| 2-Alkoxy-4-(aryl)-5H-indeno [1, 2-b] pyridine-3-carbonitriles (3a-e and 4a-e) were synthesized via multicomponent reaction from 2-aryl-methylidineindan-1-ones (1a-e), malononitrile and K2CO3 in ethanol and/or methanol. The structures of obtained compounds (3a-e and 4a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antimicrobial activities of compounds (3a-e) were tested against the five human pathogenic bacteria. Penicillin G and Ceftriaxone antibiotics were used as positive control. The results were given as MIC values (minimum inhibition concentration), and compounds 3b-d showed very high activity against Escherichia coli 111. |
| Anahtar Kelimeler |
| 1-Indanone | malononitrile | pyridine-3-carbonitrile | antimicrobial activity |
