VNTR Variant of the eNOS Gene and its Relationship with Osteoporosis in Postmenopausal Turkish Women
Yazarlar (5)
Hitit University, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Amasya Üniversitesi, Türkiye
Prof. Dr. Asker Zeki ÖZSOY
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Endocrine Metabolic and Immune Disorders Drug Targets |
| Dergi ISSN | 1871-5303 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 09-2021 |
| Cilt No | 21 |
| Sayı | 9 |
| Sayfalar | 1691 / 1695 |
| DOI Numarası | 10.2174/1871530320999200918120208 |
| Makale Linki | http://dx.doi.org/10.2174/1871530320999200918120208 |
| Özet |
| Background: Osteoporosis (OP) is the most common type of systemic bone disease characterized by low bone mass and micro-structure deterioration of bone tissue, with a consequent increase in bone fragility and fracture risk. Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS) in endothelial cells, has considerable effects on bone cell function. The objective of this case-control study was to investigate the potential association between the eNOS gene Variable Number Tandem Repeat (VNTR) variant and susceptibility of OP, in Turkish postmenopausal female patients. Methods: One hundred and fifty female patients and 100 age-matched healthy females were enrolled in the present study. The eNOS gene VNTR variant was genotyped with a polymerase chain reaction (PCR) method. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Results: The mean age of the patients was 60.32±8.65 years. It was found that the eNOS VNTR variant genotype and allele frequencies were not significantly different between the patient and control groups (p>0.05). Trial Registration: This study is registered with the code 2017-70. |
| Anahtar Kelimeler |
| Endothelial nitric oxide synthase | Nitric oxide | Osteoporosis | PCR | Variant | VNTR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 2 |
| Google Scholar | 2 |