Synthesis of 2-Substituted Benzothiazole Derivatives and Their In Vitro Anticancer Effects and Antioxidant Activities Against Pancreatic Cancer Cells
Yazarlar (6)
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | ANTICANCER RESEARCH |
| Dergi ISSN | 0250-7005 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2017 |
| Cilt No | 37 |
| Sayı | 11 |
| Sayfalar | 6381 / 6389 |
| DOI Numarası | 10.21873/anticanres.12091 |
| Makale Linki | http://ar.iiarjournals.org/content/37/11/6381.abstract |
| Özet |
| Pancreatic cancer is one of the deadliest malignancies characterized by strong resistance to almost all chemotherapeutic agents and radiotherapy. In this study, we aimed to investigate the anticancer effect, enzymatic antioxidant activity [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and total antioxidant capacity (TAC) of synthesized benzothiazole compounds against adenocarcinoma cancer cells (PANC-1). 2-((1S,2S)-2-((E)-4-nitrostyryl)cyclopent-3-en-1-yl)benzo[d]thiazole and 2-((1S,2S)-2-((E)-4-fluorostyryl) cyclopent-3-en-1-yl)benzo[d]thiazole containing 2-substituted benzothiazole group were synthesized in two steps. PANC-1 cells were treated with different concentrations of benzothiazole compounds (5, 25, 50. 75 and 100 μM) for 48 h and their cytotoxicity effects were determined by the MTT assay. To determine whether these compounds induced apoptosis, PANC-1 cells were treated with increasing concentrations of the synthetic products. Our study showed that the synthesized compounds have antiproliferative effects against PANC-1 cells and reduced cell viability. These compounds induced apoptosis of pancreatic cancer cells and at the same time reduced the activity of SOD and GPx and reduced TAC. On the basis of these findings, these synthesized benzothiazole compounds may be considered as a potential therapeutic drug against human PANC-1 cancer cells. |
| Anahtar Kelimeler |
| Benzothiazole derivative | antioxidant | apoptosis | cytotoxicity | pancreatic cancer cell |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 59 |
| Google Scholar | 82 |