Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes
Yazarlar (5)
Cumhuriyet Üniversitesi, Türkiye
Cumhuriyet Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY |
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2017 |
| Cilt No | 31 |
| Sayı | 9 |
| Sayfalar | 21938 / 0 |
| DOI Numarası | 10.1002/jbt.21938 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.21938 |
| Özet |
| Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimer's disease and other similar ailments such as dementia and vascular dementia with Lewy bodies reduce cholinergic activity in the important areas involved in cognition and memory. Prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (AChE). These six-membered carbocycles showed nice inhibitory action against AChE and human carbonic anhydrase (hCA) II and I isoforms. The hCA I, II, and AChE were efficiently inhibited by these molecules, with K values in the range of 6.70-35.85 nM for hCA I, 18.77-60.84 nM for hCA II, and 0.74-4.60 for AChE, respectively. |
| Anahtar Kelimeler |
| acetylcholinesterase | carbonic anhydrase | domino reactions | enzyme inhibition pentasubstituted cyclohexanol |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 39 |
| Google Scholar | 45 |