The relationship between coronary collateral circulation and blood high sensitivity C reactive protein levels
Yazarlar (6)
Balıkesir Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Akdeniz Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Karabük Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli ulusal dergilerde yayınlanan tam makale |
| Dergi Adı | Turk Kardiyoloji Dernegi Arsivi |
| Dergi ISSN | 1016-5169 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | Pubmed |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2011 |
| Cilt No | 39 |
| Sayı | 1 |
| Sayfalar | 23 / 28 |
| Özet |
| Objectives: We evaluated the relationship between coronary collateral circulation (CCC) and blood high-sensitivity C-reactive protein (hs-CRP) levels in patients with chronic stable coronary artery disease. Study design: The study included 104 patients who underwent coronary angiography at least one month after acute coronary event and were found to have total coronary occlusion in at least one major coronary artery. Patients with the diagnosis of acute coronary syndrome within the past month, severe valve disease, systemic disease, systemic inflammatory disease, or a history of coronary surgery or percutaneous coronary intervention were excluded. Collateral circulation was graded according to the Rentrop classification. Grades 0 and 1 were defined as poor, grades 2 and 3 were defined as good CCC. Blood hs-CRP levels were measured 1 to 7 days before coronary angiography. Results: According to the Rentrop classification, CCC was graded as 0 in 10 patients, 1 in 26 patients, 2 in 29 patients, and 3 in 39 patients. Sixty-eight patients (65.4%) had a good CCC, and 36 patients (34.6%) had a poor CCC. The two groups were similar with respect to age, sex, risk factors, medications, localization of the occluded coronary artery, and the number of occluded arteries. However, hs-CRP levels were significantly higher in patients with a poor CCC (median 5.42 mg/dl; range 2.3-9.8 mg/dl) compared to those with a good CCC (median 3.36 mg/dl; range 2.2-9.7 mg/dl, p=0.003). Logistic regression analysis showed that hs-CRP level was a significant predictor exerting an adverse effect on collateral development (β=-320; odds ratio=0.725; 95% confidence interval 0.587-0.894; p=0.003). Conclusion: Our findings suggest that high hs-CRP level is a significant predictor of poor collateral development in patients with chronic stable coronary artery disease. © 2011 Türk Kardiyoloji Derneǧi. |
| Anahtar Kelimeler |
| C-reactive protein | Collateral circulation | Coronary angiography | Coronary artery disease | Coronary stenosis |
