The Effect of Dopamine Type 2 Receptor Blockade on Autonomic Modulation
Yazarlar (6)
Dayimi Kaya Afyon Kocatepe Üniversitesi, Türkiye
Ender Ellidokuz
Afyon Kocatepe Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Ersel Onrat Afyon Kocatepe Üniversitesi, Türkiye
Hulya Ellidokuz Afyon Kocatepe Üniversitesi, Türkiye
Prof. Dr. Ataç ÇELİK Afyon Kocatepe Üniversitesi, Türkiye
Celal Kilit Afyon Kocatepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Clinical Autonomic Research (Q4) | ||
| Dergi ISSN | 0959-9851 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2003 |
| Cilt / Sayı / Sayfa | 13 / 4 / 275–280 | DOI | 10.1007/s10286-003-0097-3 |
| Makale Linki | http://link.springer.com/10.1007/s10286-003-0097-3 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Dopamine2 (D2)-like receptor antagonists are widely used for the treatment of gastroparesis and vomiting. Metoclopramide (MCP), a peripheral and central D2-like receptor antagonist, stimulates the sympathetic nervous system and may alter autonomic modulation, but the net effect of MCP to the heart is not known. The aim of our study was to investigate the effects of MCP on cardiac autonomic modulation, using power spectral analysis of heart rate variability.We evaluated the effect of MCP on cardiac autonomic modulation during prolonged supine and standing positions in 9 healthy men. We intravenously administered 10 mg MCP and placebo in a double blind and crossover manner to all participants during continuous electrocardiography recording. Placebo or MCP was administered after 15 minutes in supine position (REST phase), where participants remained for an additional 50 minutes (PSUP phase) and … |
| Anahtar Kelimeler |
| D2-like receptor | HRV | Metoclopramide | Sympathovagal balance |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 13 |
| Scopus | 15 |
| Google Scholar | 23 |