Isolation of phenolic compounds from eco-friendly white bee propolis: Antioxidant, wound-healing, and anti-Alzheimer effects
Yazarlar (8)
Harran Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Seçil ERDEN TAYHAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bilecik Şeyh Edebali Üniversitesi, Türkiye
Doç. Dr. Sema BİLGİN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Çankiri Karatekin Üniversitesi, Türkiye
Anadolu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Food Science and Nutrition |
| Dergi ISSN | 2048-7177 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 12 |
| Sayı | 3 |
| Sayfalar | 1928 / 1939 |
| DOI Numarası | 10.1002/fsn3.3888 |
| Makale Linki | http://doi.org/10.1002/fsn3.3888 |
| Özet |
| This study presents the first findings regarding extraction, isolation, enzyme inhibition, and antioxidant activity. The oral mucosal wound-healing process was investigated using propolis water extract (PWE) incubation with gingival fibroblast cells and concluded that propolis was effective on the oral mucosal wound-healing pattern compared to untreated controls. Additionally, phenolic compounds (fraxetin, apigenin, galangin, pinobanksin, chrysin, etc.) were isolated from propolis, and their chemical structures were elucidated using comprehensive spectroscopic methods. The antioxidant and anti-Alzheimer potential activities of PWE and some isolated compounds were screened and revealing their inhibitory effects on acetylcholinesterase (AChE) with IC values ranging from 0.45 ± 0.01 to 1.15 ± 0.03 mM, as well as remarkable free-radical scavenging and metal reduction capacities. The results suggest that these compounds and PWE can be used as therapeutic agents due to their antioxidant properties and inhibitory potential on AChE. It can also be used for therapeutic purposes since its wound-healing effect is promising. |
| Anahtar Kelimeler |
| anti-Alzheimer | antioxidant capacity | isolation of phenolics | phytochemical | propolis | wound-healing |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 22 |
| SCOPUS | 23 |
| Google Scholar | 34 |