Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
Yazarlar (4)
Yozgat Bozok Üniversitesi, Türkiye
Doç. Dr. Aykut ÖZGÜR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Bioorganic and Medicinal Chemistry |
| Dergi ISSN | 0968-0896 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2013 |
| Cilt No | 21 |
| Sayı | 13 |
| Sayfalar | 3859 / 3865 |
| DOI Numarası | 10.1016/j.bmc.2013.04.021 |
| Makale Linki | https://www.sciencedirect.com/science/article/abs/pii/S0968089613003477?via%3Dihub |
| Özet |
| In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in good yield through one pot reaction of 4-benzoyl-1, 5-diphenyl-1H-pyrazole-3-carbonyl chloride with ammonium thiocyanate and various amines. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and elemental analysis. Anticancer activities of synthesized compounds were evaluated on human colon, liver and leukemia cancer cell lines. Cell culture studies have demonstrated significant toxicity of the compounds on the cell lines, and the levels of toxicity have altered in the presence of various side groups. These results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment. Furthermore, these compounds have a great potential and significance for further investigations. © 2013 Elsevier Ltd. All rights reserved. |
| Anahtar Kelimeler |
| Acyl thiourea | Anticancer activity | Colon | Leukemia cell lines | Liver | Pyrazole |
Science Direct
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 215 |
| Google Scholar | 239 |