| Makale Türü |
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| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Drug Development Research |
| Dergi ISSN | 0272-4391 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 76 |
| Sayı | 7 |
| Sayfalar | 382 / 388 |
| DOI Numarası | 10.1002/ddr.21273 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/epdf/10.1002/ddr.21273 |
| Özet |
| Preclinical Research The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types and are respectively categorized as oncogenes (oncomirs) or tumor suppressors. Expression profiles of miRNAs with biomarker potential can be used for the classification, diagnosis, therapeutic treatment, and prognosis of different cancer types. miRNA mimics and miRNA antagonists are the two main approaches to miRNA-based cancer therapies that respectively inhibit oncomirs or restore the expression of tumor suppressive miRNAs. This review serves to provide some general insight into miRNA biogenesis, cancer related miRNAs, and miRNA therapeutics. |
| Anahtar Kelimeler |
| cancer | microRNA | oncomir | therapeutics | tumor suppressor |
| Atıf Sayıları | |
| SCOPUS | 62 |
| Google Scholar | 84 |
| Dergi Adı | DRUG DEVELOPMENT RESEARCH |
| Yayıncı | John Wiley & Sons Inc. |
| Açık Erişim | Hayır |
| ISSN | 0272-4391 |
| E-ISSN | 1098-2299 |
| CiteScore | 6,6 |
| SJR | 0,756 |
| SNIP | 0,805 |