DNA repair pathways and their roles in drug resistance for lung adenocarcinoma
Yazarlar (4)
Research Institute For Genetic Engineering And Biotechnology, Türkiye
Doç. Dr. Aykut ÖZGÜR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Research Institute For Genetic Engineering And Biotechnology, Türkiye
Research Institute For Genetic Engineering And Biotechnology, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Molecular Biology Reports |
| Dergi ISSN | 0301-4851 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2021 |
| Cilt No | 48 |
| Sayı | 4 |
| Sayfalar | 3813 / 3825 |
| DOI Numarası | 10.1007/s11033-021-06314-z |
| Makale Linki | https://link.springer.com/article/10.1007/s11033-021-06314-z |
| Özet |
| Lung cancer is the leading cancer type of death rate. The lung adenocarcinoma subtype is responsible for almost half of the total lung cancer deaths. Despite the improvements in cancer treatment in recent years, lung adenocarcinoma patients’ overall survival rate remains poor. Immunetherapy and chemotherapy are two of the most widely used options for the treatment of cancer. Although many cancer types initially respond to these treatments, the development of resistance is inevitable. The rapid development of drug resistance mainly characterizes lung adenocarcinoma. Despite being the subject of many studies in recent years, the resistance initiation and progression mechanism is still unclear. In this review, we have examined the role of the primary DNA repair pathways (non-homologous end joining (NHEJ) pathway, homologous-recombinant repair (HR) pathway, base excision repair (BER) pathway, and nucleotide excision repair (NER) pathway and transactivation mechanisms of tumor protein 53 (TP53) in drug resistance development. This review suggests that mentioned pathways have essential roles in developing the resistance against chemotherapy and immunotherapy in lung adenocarcinoma patients. |
| Anahtar Kelimeler |
| Cancer | DNA repair | Drug resistance | Lung | Lung adenocarcinoma | Oncology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 25 |
| Google Scholar | 36 |