THE DETERMINATION OF TOXICITY AND PHARMACOKINETICS PARAMETERS OF SOME IMPORTANT CENTRAL NERVOUS SYSTEM DEPRESSANTS BY USING IN SILICO METHODS (HEALTH & SCIENCE 2024-I)
Yazarlar (2)
Prof. Dr. Mustafa Tuğfan BİLKAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Çiğdem BİLKAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Bölüm Adı | THE DETERMINATION OF TOXICITY AND PHARMACOKINETICS PARAMETERS OF SOME IMPORTANT CENTRAL NERVOUS SYSTEM DEPRESSANTS BY USING IN SILICO METHODS | ||
| Kitap Adı | HEALTH & SCIENCE 2024-I | ||
| Bölüm Sayfaları | 29-42 | ||
| Kitap Türü | Kitap Bölümü | ||
| Kitap Alt Türü | Alanında uluslararası yayınlanan kitap bölümü | ||
| Kitap Niteliği | Diğer uluslararası bilimsel kitap | ||
| Kitap Dili | İngilizce | Basım Tarihi | 01-2024 |
| DOI Numarası | – | ISBN | 978-625-392-049-4 |
| Basıldığı Ülke | Türkiye | Basıldığı Şehir | İstanbul |
| Kitap Linki | https://www.google.com.tr/books/edition/HEALTH_SCIENCE_2024_I/HeQGEQAAQBAJ?hl=tr&gbpv=0 | ||
| UAK Araştırma Alanları |
Sosyal, Beşeri ve Idari Bilimler
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| Özet |
| Central nervous system depressants (CNSD) slow down brain activity and thus induce sedation and muscle relaxation (Stafford et al., 2005). They also suppress excitation in various brain regions by reducing neurotransmission (Bloom, 2006). They are basically used to treat major psychological disorders such as anxiety, sleep disorders, acute stress reactions, mental illness, and panic disorders. These diseases result from the significant effects of the modern world on human psychology, and today, it is known that a significant number of people use central nervous system depressants against these diseases. There are many types of depressants prescribed by physicians because they are used for therapeutic purposes. For example, benzodiazepine-like drugs are the most commonly prescribed drug group in the treatment of sleep problems. Benzodiazepines and barbiturates (a category of sedative-hypnotic medications) increase Cl− influx at the GABA receptor complex and thus cause resultant membrane hyperpolarization and decreased neuronal activity (Giovannitti, et al.,(2017). Common effects of depressants include anxiolysis, ataxia, sedation, pain relief, and cognitive impairment. In addition, muscle relaxation, respiratory depression, decrease in heart rate, euphoria, and anticonvulsant effects are among the effects that can be seen as a result of depressant use (Mihic & Harris, 2011). One of the most common known depressants is also alcohol. Alcohol has both stimulant and sedative effects on humans. Although it is known that the mechanism that produces the stimulating effects is the triggering of striatal dopamine release, there is no … |
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