Protective effects of melatonin on female rat ovary treated with nonylphenol.
Yazarlar (9)
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Türkiye
Dr. Öğr. Üyesi Ayşe CEYHAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Türkiye
Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biotechnic & Histochemistry |
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2022 |
| Cilt No | 98 |
| Sayı | 1 |
| Sayfalar | 13 / 19 |
| DOI Numarası | 10.1080/10520295.2022.2075566 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2022.2075566 |
| Özet |
| We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) and the protective effect of melatonin treatment of NP induced ovarian damage. We used 21 female rats divided randomly into three groups: control, NP and melatonin + NP. Histopathological examination of the ovaries, and counting and classification of follicles were performed using Masson's trichrome staining. Expression of anti-Mullerian hormone (AMH), Bax, Bcl-2 and caspase-3 was detected in the ovaries using immunohistochemistry. Melatonin had an ameliorative effect on NP induced follicular atresia and absence of corpora lutea. More follicles were observed in the ovaries of animals treated with melatonin prior to treatment with NP. AMH immunoreactivity was significantly lower in the NP group than in the melatonin + NP group. NP increased immunostaining for Bax, Bcl-2 and caspase-3. Melatonin significantly reduced the increased expression of Bax, Bcl-2 and caspase-3 due to NP exposure. We found that pretreatment with melatonin is beneficial for protecting the ovaries from damage by NP. |
| Anahtar Kelimeler |
| Anti-Mullerian hormone (AMH) | apoptosis | melatonin | nonylphenol | ovary | rats |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |
| Google Scholar | 14 |