Effects of long term starvation and refeeding on fatty acid metabolism relatedgene expressions in the liver of zebrafish Danio rerio
Yazarlar (4)
Dr. Öğr. Üyesi Ayşe ÖLMEZ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Huazhong Agricultural University, Çin
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Veterinary and Animal Sciences |
| Dergi ISSN | 1300-0128 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Exp, SCOPUS, Curation, Essential Science Indicators, Pdf2xml, Pdf2xml, Reference Master, Sophia |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2015 |
| Cilt No | 39 |
| Sayı | 6 |
| Sayfalar | 654 / 660 |
| DOI Numarası | 10.3906/vet-1507-54 |
| Makale Linki | http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=vet-1507-54 |
| Özet |
| A 70-day starvation was conducted to determine the effects of long-term starvation on whole-body polyunsaturated fatty acid (PUFA) composition and fatty acid metabolism-related gene expression in the liver of zebrafish, Danio rerio. The starvation period was followed by a 15-day refeeding period to test recovery of both PUFA composition and gene expression levels. It was found that n-3 PUFA and arachidonic acid levels increased during starvation and returned to normal values after refeeding (P < 0.05). Expression of seven (elovl5, fads2, cpt1-β, acox1, acadvl, fabp1a,and fabp7a) of eight total genes downregulated significantly towards the end of the starvation. As a result of refeeding, gene expression of elovl5 and ppar-α returned to the normal levels. Therefore, it was concluded that, in general, mRNA expression of genes involved in fatty acid metabolism was negatively influenced by long-term starvation (70 days); there was no direct relationship between whole-body fatty acid composition and hepatic gene expressions; and 15-day refeeding was insufficient for recovery of starvation-based metabolic losses in zebrafish. |
| Anahtar Kelimeler |
| Lipid metabolism | starvation | mRNA transcription | qPCR | zebrafish |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 16 |
| SCOPUS | 16 |
| TRDizin | 1 |
| Google Scholar | 20 |