Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
Yazarlar (5)
Doç. Dr. Engin KÖLÜKÇÜ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Doç. Dr. Fatih FIRAT
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Türk Biyokimya Dergisi |
| Dergi ISSN | 1303-829X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2024 |
| Cilt No | 49 |
| Sayı | 3 |
| Sayfalar | 439 / 445 |
| DOI Numarası | 10.1515/tjb-2023-0237 |
| Makale Linki | http://dx.doi.org/10.1515/tjb-2023-0237 |
| Özet |
| Objectives We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous-associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were … |
| Anahtar Kelimeler |
| diacerein | partial ureteral obstruction | oxidative damage |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |