Cholinesterase inhibition and molecular docking studies of sesquiterpene coumarin ethers from Heptaptera cilicica
Yazarlar (6)
Prof. Dr. Zühal Güvenalp Atatürk Üniversitesi, Türkiye
Prof. Dr. Hilal Özbek Atatürk Üniversitesi, Türkiye
Kadir Özden Yerdelen
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Doç. Dr. Gülderen YILMAZ Ankara Üniversitesi, Türkiye
Prof. Dr. Cavit Kazaz Atatürk Üniversitesi, Türkiye
Lütfiye Ömür Demirezer
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Records of Natural Products | ||
| Dergi ISSN | 1307-6167 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 11 / 5 / 462–467 | DOI | 10.25135/rnp.58.17.03.051 |
| UAK Araştırma Alanları |
Farmasotik Botanik
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| Özet |
| Five sesquiterpene coumarin ethers: umbelliprenin, umbelliprenin-10',11'-monoepoxide, conferone, mogoltacin and feselol were isolated from the fruits of Heptaptera cilicica. Their structures were identified by means of spectroscopic methods. AChE and BuChE inhibitory activities of the compounds were determined by molecular docking method which were confirmed by in vitro experiments. According to molecular docking results, total score of feselol and umbelliprenin were 5.69 and 3.23 kcal/mol against acetylcholinesterase, respectively. Total score for butyrylcholinesterase inhibitory effect of them were 2.76 and 4.99 kcal/mol, respectively. Feselol and umbelliprenin exhibited significantly high inhibitory potency against acetylcholinesterase (IC |
| Anahtar Kelimeler |
| Acetylcholinesterase | Butyrylcholinesterase | Heptaptera cilicica | Sesquiterpene coumarin ether |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 14 |