The synthesis and characterization of novel lawsone derivative molecules: their influence on cell lysis in ovarian granulosa cells in vitro
Yazarlar (5)
Mehmet Emin Çakmak Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Kıymet BERKİL AKAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Çağlar BERKEL Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Oğuz ÖZBEK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Meliha Burcu GÜRDERE Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemical Papers (Q3) | ||
| Dergi ISSN | 0366-6352 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 80 / 8 / 8969–8976 | DOI | 10.1007/s11696-026-04930-2 |
| Makale Linki | https://doi.org/10.1007/s11696-026-04930-2 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| In the present study, five novel lawsone derivative molecules (3a–e) containing a 2-phenylthiazole unit were synthesized for the first time, and the structures of these compounds were confirmed based on their spectral data (1H–NMR, 13C–NMR and FT–IR). Besides, the influence of these new lawsone derivative molecules on cell lysis (plasma membrane rupture) were studied in ovarian granulosa cells (KGN cell line) by comparing the levels of LDH (lactate dehydrogenase) released from these cells invitro. LDH release is widely used as a quantitative marker of plasma membrane damage and lytic cell death, allowing the reliable assessment of cytotoxic or cytoprotective effects. We found that molecule 3b slightly increased cell lysis by ~ 8%, whereas molecule 3e decreased cell lysis by ~ 10% in granulosa cells, suggesting that some of these lawsone derivative molecules might be able to modulate plasma … |
| Anahtar Kelimeler |
| Granulosa cells | Inflammation | Lawsone | Lytic cell death | Ovarian cells | Plasma membrane rupture |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |