Cholecalciferol vitamin D 3 improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndrome
Yazarlar (6)
İstanbul Bilim Üniversitesi, Türkiye
Trakya Üniversitesi, Türkiye
Prof. Dr. Dürdane AKSOY
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Life Sciences |
| Dergi ISSN | 0024-3205 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2014 |
| Cilt No | 103 |
| Sayı | 2 |
| Sayfalar | 68 / 72 |
| DOI Numarası | 10.1016/j.lfs.2014.03.035 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0024320514003890 |
| Özet |
| The aim of this study was to examine the effects of cholecalciferol on systemic inflammation and memory in the setting of fatty liver disease in rats. To induce the development of fatty liver disease, the rats were fed a 35% fructose solution over 8 weeks. Group I (n=6) was designated as the control group and fed with standard rat chow. Group II (n=6) was provided with, standard rat chow, and 0.3 μg/kg/day of oral cholecalciferol over a duration of 2 weeks. In addition to standard rat chow, group III (n=6) and group IV (n=6) were given 4 mL of the 35% fructose solution per day via oral gavage for 8 weeks. However, group IV was also given 0.3 μg/kg/day of oral cholecalciferol over 2 weeks. After the treatment period, passive avoidance tasks were performed by all groups. The liver and brain were harvested for subsequent biochemical and histopathologic analyses. The development of fatty liver extends the memory latency period of passively avoiding tasks after 1 trial. Moreover, there were increases in brain TNF-α and plasma MDA levels according to two-way analysis of variance. Cholecalciferol supplementation decreased the latency period of passively avoiding tasks in rats with hepatosteatosis, and also significantly reduced brain TNF-α and plasma MDA levels. Fatty liver may contribute to the development of systemic inflammation, which affects cognition and causes deficits in memory; however, the anti-inflammatory and antioxidant properties of vitamin D may improve the cognitive function of rats with hepatosteatosis. |
| Anahtar Kelimeler |
| Fatty liver | Memory functions | Inflammation | Cholecalciferol |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 41 |
| Google Scholar | 71 |