The Correlation between Rs1800795 Variant of IL-6 and Sports Performance among Turkish Elite Athletes
Yazarlar (6)
Prof. Dr. Abdullah CANİKLİ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hitit Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | International Journal of Humanities, Social Sciences and Education |
| Dergi ISSN | 2349-0381 |
| Dergi Tarandığı Indeksler | Index Copernicus |
| Makale Dili | Türkçe |
| Basım Tarihi | 11-2016 |
| Cilt No | 3 |
| Sayı | 11 |
| Sayfalar | 1 / 5 |
| DOI Numarası | 10.20431/2349-0381.0311001 |
| Makale Linki | https://www.arcjournals.org/pdfs/ijhsse/v3-i11/1.pdf |
| Özet |
| Background: It has been reported that plasma levels of interleukin-6 (IL-6) increase during physical exercise and are involved in mediating endurance capacity. We compared allelic and genotypic frequencies of the IL-6 gene G174C variant (rs1800795) among elite athletes and non-athletic control subject.Materials Methods: The study included 92 elite Turkish athletes and 100 non-athletes. Genomic DNA isolated and genotyped using polymerase chain reaction based-restriction fragment length polymorphism (PCR-RFLP) analysis for the IL-6 gene G174C variant.Results: In this study, the allele distribution of IL-6 gene G174C variant exhibited statistically significant difference between the elite athletes and the controls (p= 0.005). The G allele was more prevalent among the elite athletes than the control subjects. The genotype frequencies in the studied population were as follows: GG, GC, and CC in the controls were 40%, 45% and 15%, and in the elite athletes were 50%, 43.5%, and 6.5%, respectively. However, there was not any statistically significant difference in the genotype frequencies of the IL-6 G174C variant between the elite athletes and the control groups (p> 0.05).Conclusion: Our study suggests that a strong association exists between the IL-6 G174C variant and elite endurance performance in the Turkish population. Further studies in populations of different ethnic background are necessary to prove the association of IL-6 variant with sports performance. |
| Anahtar Kelimeler |