A case-control study investigating the effect of MTHFR C677T variant on performance of elite athletes
Yazarlar (4)
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Serbülent Yiğit Türkiye
Hüsniye Rüstemoğlu
Prof. Dr. Abdullah CANİKLİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (Q4) | ||
| Dergi ISSN | 1871-5303 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | 25-08-2020 | Yayınlanma Tarihi | 01-09-2021 |
| Cilt / Sayı / Sayfa | 21 / 9 / 1685–1690 | DOI | 10.2174/1568026620666201022144819 |
| Makale Linki | http://dx.doi.org/10.2174/1568026620666201022144819 | ||
| Özet |
| Objective Increased level of plasma homocysteine (Hcy) is a potential risk factor for several multi-system diseases. The Methylenetetrahydrofolate reductase (MTHFR) gene C677T variant has been established as an important genetic determinant of hyperhomocysteinemia. There are conflicting reports about the effects of physical activity on plasma Hcy. Therefore, the main aim of this study was to investigate whether the MTHFR C677T variant affects elite athletic performance. Methods This study was carried out on 214 individuals (114 elite athletes and 100 sedentary controls). Genotyping was performed using PCR- RFLP method. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results There was a significant difference between the athletes and the control group in genotype distribution and allele frequency of the MTHFR C677T variant. MTHFR C677T CC … |
| Anahtar Kelimeler |
| Sport performance | MTHFR | C677T | variant | sedentary | homocysteine (Hcy) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 3 |
| Web of Science | 2 |