Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis
Yazarlar (9)
Doç. Dr. Elif KAYA ÇELİK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ünsal Han
Murad Mutlu
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Güleser Saylam Sağlık Bilimleri Üniversitesi, Türkiye
Kemal Keseroğlu
Türkiye
Türkiye
Ömer Bayır
Türkiye
Türkiye
Emel Çadallı Tatar
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
İstemihan Akın
Türkiye
Türkiye
Mehmet Hakan Korkmaz
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | B-ENT (Q4) | ||
| Dergi ISSN | 1781-782X | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2022 |
| Cilt / Sayı / Sayfa | 18 / 3 / 184–189 | DOI | 10.5152/B-ENT.2022.21096 |
| Makale Linki | https://doi.org/10.5152/b-ent.2022.21096 | ||
| Özet |
| Objective: This study aimed to investigate the expression of estrogen receptor beta 2 receptor in laryngeal squamous cell carcinomas and its relationship with lymph node metastasis. Methods: Histopathological specimens of laryngeal squamous cell carcinoma patients who underwent laryngectomy and neck dissection were evaluated retrospectively. The patients were divided into 2 groups according to the presence of lymph node metastasis. Estrogen receptor beta 2, Ki-67, and p53 antibodies were studied by immunohistochemical methods in the tumoral and non-tumoral tissue specimens. The evaluation of immunohistochemical staining pattern was evaluated with Allred scores. The difference between tumoral and non-tumoral tissues of estrogen receptor beta 2 Allred scores and the relationship of lymph node metastasis with Allred scores of estrogen receptor beta 2 were examined and correlated with Ki-67 and p53 expression. Results: This study included 26 patients in lymph node metastasis (+) group and 46 patients in lymph node metastasis (−) with a total number of 72 patients. There was a significantly higher estrogen receptor beta 2 Allred score of tumoral tissue with respect to non-tumoral tissue (P < .001). Nevertheless, there was no significant relationship between lymph node metastasis (+) group and lymph node metastasis (−) group according to tumoral tissue ERβ2 Allred score (P=.092). Conclusion: Estrogen receptor beta 2 expression was demonstrated significantly in the tumoral tissue of the laryngeal squamous cell carcinoma patients Cite this article as: Kaya Çelik E, Han Ü, Mutlu M, et al. Expression of estrogen receptor beta 2 in laryngeal cancer and its relationship with lymph node metastasis. B-ENT 2022;18(3):184-189. |
| Anahtar Kelimeler |
| Laryngeal squamous cell carcinoma | lymph node metastasis | ERI32 | Ki67 | P53 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |