Protective Effects of Syringic Acid on Ischemia-Reperfusion Injury in Testicular Torsion: An Experimental Study in a Rat Model
Yazarlar (4)
Kubilay Sarıkaya
Türkiye
Türkiye
Doç. Dr. Engin KÖLÜKÇÜ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Velid Unsal Mardin Artuklu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Süleyman ÖZDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | CUREUS JOURNAL OF MEDICAL SCIENCE | ||
| Dergi ISSN | 2168-8184 Wos Dergi | ||
| Dergi Tarandığı Indeksler | Web of Science-Emerging Sources Citation Index (ESCI) | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 24-07-2023 |
| Cilt / Sayı / Sayfa | 15 / 7 / 42390–42390 | DOI | 10.7759/cureus.42390 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/37492038/ | ||
| Özet |
| The purpose of this study was to assess the effectiveness of syringic acid in preventing ischemia-reperfusion injury following detorsion in a rat model of induced testicular torsion. In our study, a total of 24 rats, eight in each group, were used. Group 1 served as the control group. Group 2 underwent testicular torsion and detorsion. Group 3 underwent the same procedures as Group 2, but also received 100 mg/kg syringic acid immediately following ischemia. Spectrophotometric analysis was performed on blood samples, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as the values of malondialdehyde (MDA), were evaluated under direct microscopic examination of the testis to determine tissue injury. The architecture of the seminiferous tubules and spermatogenesis processes were graded using the Johnsen and Cosentino scoring systems. The mean value of MDA was higher in Group 2 compared to the other groups (p < 0.001). Group 3 demonstrated a decline in the concentrations of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta, as indicated by biochemical analysis of blood samples, when compared to Group 2 (p-values: 0.045, 0.001, and <0.001, respectively). In addition, the improvement in Johnsen and Cosentino scores was significantly higher in Group 3 compared to Group 2 (p = 0.028 and p = 0.001, respectively). These findings suggest that syringic acid has a protective effect against testicular oxidative damage. |
| Anahtar Kelimeler |
| oxidative damage | wistar rat | oxidant | reperfusion injury | testicular torsion |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |