Dapsone can be a new treatment option for reducing the detrimental effect of priapism
Yazarlar (6)
Doç. Dr. Engin KÖLÜKÇÜ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Bekir Süha PARLAKTAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Nihat ULUOCAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mardin Artuklu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale |
| Dergi Adı | Journal of health sciences and medicine (Online) |
| Dergi ISSN | 2636-8579 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2021 |
| Cilt No | 4 |
| Sayı | 6 |
| Sayfalar | 800 / 808 |
| DOI Numarası | 10.32322/jhsm.963439 |
| Makale Linki | https://dergipark.org.tr/en/pub/jhsm/issue/64996/963439 |
| Özet |
| Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats. Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism. Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) values compared with Group 2 (p:0.002, p:0.029 and p:0.009, respectively). The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p<0.001). Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF alpha) levels were found to be significantly decreased in Group 3 compared with Group 2 (p:0.022, p:0.049 and p<0.001, respectively). Direct microscopic evaluation determined an improvement in inflammation, edema, desquamation and vasocongestion scores in Group 3 compared to Group 2 (p<0.05). Conclusion: Dapsone has a protective effect on ischaemia-reperfusion injury in corporal tissue. |
| Anahtar Kelimeler |
| Dapsone | priapism | ischaemia reperfusion injury | treatment |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 1 |