Milrinone ameliorates ischaemia-reperfusion injury in experimental testicular torsion/detorsion rat model
Yazarlar (6)
Doç. Dr. Engin KÖLÜKÇÜ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Doğan ATILĞAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Nihat ULUOCAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mardin Artuklu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | ANDROLOGIA |
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2021 |
| Cilt No | 53 |
| Sayı | 8 |
| Sayfalar | 14128 / 0 |
| DOI Numarası | 10.1111/and.14128 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/34091938 |
| Özet |
| This experimental study aims to evaluate the efficacy of milrinone against ischaemia-reperfusion injury due to testicular torsion/detorsion. Group 1 was defined as the control group. Testicular torsion/detorsion model was performed in Group 2. Group 3 had similar procedures to the rats in Group 2. In addition, 0.5 mg/kg of milrinone was administered intraperitoneally immediately after testicular torsion in Group 3. Histopathological examinations indicated a dramatic improvement in terms of inflammation, haemorrhage, oedema, congestion, Cosentino and Johnson scores in Group 3 compared to Group 2 (p = .037, p = .045, p = .018, p = .040, p = .033 and p = .03 respectively). Blood biochemical analyses, superoxide dismutase (SOD), glutathione peroxidase (GSH-px) activity and total antioxidant status (TAS) levels increased significantly in Group 3 compared to Group 2 (p = .001, p = .024 and p < .001). Malondialdehyde (MDA), protein carbonyl (PC), interleukin 1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and total oxidant status (TOS) levels decreased in Group 3 compared to Group 2 (p = .001, p = .018, p < .001, p = .036 and p = .002 respectively). Tissue biochemical analyses determined an increase in SOD and GSH-px activity in Group 3 compared to Group 2, while PC and MDA levels were reduced (p = .001, p < .001, p = .038 and p < .001 respectively). Milrinone attenuates ischaemia-reperfusion injury that causes highly harmful effects due to testicular torsion/detorsion. |
| Anahtar Kelimeler |
| ischaemia-reperfusion injury | milrinone | testicular torsion | treatment |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 26 |