Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism
Yazarlar (8)
Doç. Dr. Engin KÖLÜKÇÜ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Bekir Süha PARLAKTAŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Vildan KÖLÜKÇÜ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Faik Alev Deresoy
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Öğr. Gör. Yunus Emre KUYUCU Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Velid Unsal Mardin Artuklu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ANDROLOGIA (Q4) | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2021 |
| Kabul Tarihi | 05-01-2021 | Yayınlanma Tarihi | 21-01-2021 |
| Cilt / Sayı / Sayfa | 53 / 3 / 13985–0 | DOI | 10.1111/and.13985 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1111/and.13985 | ||
| Özet |
| The study aimed to investigate the effects of dexmedetomidine against ischaemia-reperfusion injury occurring after priapism in a model of induced-priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia-reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro-inflammatory cytokines including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was in Group 2 (p:.002). The levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were significantly higher in Group 3 than that of Group 2 (p:.037 and p:.045, respectively). Direct microscopic examinations revealed positive changes in desquamation, oedema, inflammation and vasocongestion scores in Group 3 compared to Group 2 (p:.007, p:.008, p:.007 and p:.006, respectively). Dexmedetomidine has a protective effect against ischaemia-reperfusion injury in penile tissue. |
| Anahtar Kelimeler |
| dexmedetomidine | ischaemia reperfusion injury | priapism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |