The class II transactivator CIITA is regulated by post translational modification cross talk between ERK1 2 phosphorylation mono ubiquitination and Lys63 ubiquitination
Yazarlar (5)
Georgia State University, Amerika Birleşik Devletleri
Georgia State University, Amerika Birleşik Devletleri
Georgia State University, Amerika Birleşik Devletleri
Prof. Dr. Ercan ÇAÇAN
Georgia State University, Amerika Birleşik Devletleri
Georgia State University, Amerika Birleşik Devletleri
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Bioscience Reports |
| Dergi ISSN | 0144-8463 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2015 |
| Cilt No | 35 |
| Sayı | 4 |
| Sayfalar | 233 / 233 |
| DOI Numarası | 10.1042/BSR20150091 |
| Makale Linki | http://bioscirep.org/cgi/doi/10.1042/BSR20150091 |
| Özet |
| The class II transactivator (CIITA) is known as the master regulator for the major histocompatibility class II (MHC II) molecules. CIITA is dynamically regulated through a series of intricate post-translational modifications (PTMs). CIITA's role is to initiate transcription of MHC II genes, which are responsible for presenting extracellular antigen to CD4+T-cells. In the present study, we identified extracellular signal-regulated kinase (ERK)1/2 as the kinase responsible for phosphorylating the regulatory site, Ser280, which leads to increased levels of mono-ubiquitination and an overall increase in MHC II activity. Further, we identify that CIITA is also modified by Lys63-linked ubiquitination. Lys63 ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys= ubiquitinated CIITA translocates to the nucleus. CIITA ubiquitination and phosphorylation perfectly demonstrates how CIITA location and activity is regulated through PTM cross-talk. Identifying CIITA PTMs and understanding how they mediate CIITA regulation is necessary due to the critical role CIITA has in the initiation of the adaptive immune response. |
| Anahtar Kelimeler |
| Immunology | Protein regulation | Transcription regulation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 18 |
| Google Scholar | 22 |