LC-ESI-MS/MS analysis, toxicity and anti-anaemic activity of Rubia tinctorum L. aqueous extract
Yazarlar (5)
Fatima Zohra Houari Université Mustapha Stambouli De Mascara, Cezayir
Prof. Dr. Ramazan ERENLER Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sena Bakir İstanbul Teknik Üniversitesi, Türkiye
Esra Capanoglu İstanbul Teknik Üniversitesi, Türkiye
Ahmed Hariri Université Mustapha Stambouli De Mascara, Cezayir
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Nova Biotechnologica Et Chimica | ||
| Dergi ISSN | 1338-6905 Dergi Bilgileri (2022) | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2022 |
| Cilt / Sayı / Sayfa | 21 / 1 / – | DOI | 10.36547/nbc.978 |
| Makale Linki | https://www.cabidigitallibrary.org/doi/full/10.5555/20220282127 | ||
| UAK Araştırma Alanları |
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| Özet |
| The present study investigated the chemical profile, toxicity, and anti-anaemic activity of Rubia tinctorum root aqueous extract against phenylhydrazine induced hemolytic anaemia. Phenolic compounds were analyzed by LC-ESI-MS/MS; acute toxicity test was evaluated by administering a single dose of 2,000 mg.kg-1 of the extract; anaemia was induced by administration of 40 mg phenylhydrazine by intraperitoneal injection for 2 days. Moreover, the anti-anaemic activity was evaluated by measuring the haematological parameters of rats treated with iron and aqueous extract for 15 days. The LC-ESI-MS/MS analysis results revealed the presence of 31 phytochemical compounds, among them, citric acid was found as the most abundant. No signs of toxicity or death were recorded, indicating that the LD50 of R. tinctorum root extract is higher than 2,000 mg.kg-1. Furthermore, the aqueous extract increased red … |
| Anahtar Kelimeler |
| Antianaemic | Phytochemical analysis | Rubiaceae | Toxic effect |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 2 |
| Google Scholar | 2 |