The Use of Sequential VEGF and BMP2 Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects
Yazarlar (6)
Nilufer Cakir-Ozkan
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Sinan EĞRİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Esengül ŞEN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
B. Zuhal Altunkaynak
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Yonca Betil Kabak Ondokuz Mayis Üniversitesi, Türkiye
Elfide Gizem Kivrak
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Oral and Maxillofacial Surgery (Q2) | ||
| Dergi ISSN | 0278-2391 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 75 / 1 / 221–221 | DOI | 10.1016/j.joms.2016.08.020 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0278239116307546 | ||
| Özet |
| PurposePromising developments have materialized in reconstructive surgical procedures with the applications of tissue engineering. In our study, we used tissue scaffolds fabricated from polylactic acid-polyethylene glycol (PLLA-PEG) copolymers to ensure different release rates of selective growth factors recombinant human bone morphogenetic protein 2 [rhBMP-2] and vascular endothelial growth factor (rhVEGF165) in the repair of mandibular bone defects.Materials and MethodsIn our experimental study, 54 New Zealand rabbits were used. The rabbits were separated into 4 groups: group I (control group), PLLA-PEG scaffold only; group II, PLLA-PEG scaffold plus rhBMP-2 application; group III, PLLA-PEG scaffold plus VEGF165 application; and group IV, PLLA-PEG scaffold plus rhBMP-2 and VEGF165 applications. The rabbits were killed at 4 and 8 weeks postoperatively, and histopathologic and … |
| Anahtar Kelimeler |
Science Direct
The Use of Sequential VEGF and BMP2 Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 47 |
| Scopus | 35 |
| Web of Science | 28 |