Self-emulsifying drug delivery systems: A comparison of dry and wet reverse micelles
Yazarlar (7)
Dr. Öğr. Üyesi Numan ECZACIOĞLU Universität Innsbruck, Avusturya
Annıka Postına Universität Innsbruck, Avusturya
Melanıe Ebert Universität Innsbruck, Avusturya
Flavıa Laffleur Universität Innsbruck, Avusturya
Gergely Kalı Universität Innsbruck, Avusturya
Anna Seybold Universität Innsbruck, Avusturya
Andreas Bernkop-Schnurch Universität Innsbruck, Avusturya
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Acta Biomaterialia (Q1) | ||
| Dergi ISSN | 1742-7061 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2025 |
| Cilt / Sayı / Sayfa | 202 / 1 / 545–558 | DOI | 10.1016/j.actbio.2025.07.027 |
| Makale Linki | https://doi.org/10.1016/j.actbio.2025.07.027 | ||
| UAK Araştırma Alanları |
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| Özet |
| This study aimed to compare the performance of dry reverse micelles (dRMs) and wet reverse micelles (wRMs) in self-emulsifying drug delivery systems (SEDDS). Reverse micelles (RMs) were formed using cationic, amphoteric, and non-ionic surfactants with various model dyes incorporated into these RMs. Reverse critical micellar concentration (rCMC), entrapment efficiency (EE), and partition coefficients (logD) were determined. SEDDS were loaded with RMs, and their size distributions, polydispersity index (PDI), and zeta potential were evaluated. Cytotoxicity levels, cellular uptake, and membrane permeability of Caco-2 cells were tested. Furthermore, horseradish peroxidase (HRP) loaded SEDDS-RMs were administered to rats, and plasma HRP concentration and bioavailability were determined. Sorbitan monooleate-based dRMs exhibited an rCMC of 0.95 % and 0.6 % for wRMs, with R values of 4.7 and 43 ... |
| Anahtar Kelimeler |
| SEDDS; Dry reverse micelles; Wet reverse micelles; Cellular uptake;Transwell permeability; Bioavailability |
Science Direct
Self-emulsifying drug delivery systems: A comparison of dry and wet reverse micelles
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 11 |
| Google Scholar | 13 |
| PubMed | 4 |