The effect of hemoglobin variants on high-performance liquid chromatography measurements of glycated hemoglobin
Yazarlar (2)
Niğde Ömer Halisdemir Üniversitesi, Türkiye
Dr. Öğr. Üyesi Figen GÜZELGÜL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | International Journal of Medical Biochemistry |
| Dergi ISSN | 2587-2362 Scopus Dergi |
| Dergi Tarandığı Indeksler | Scopus |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 4 |
| Sayı | 1 |
| Sayfalar | 25 / 28 |
| DOI Numarası | 10.14744/ijmb.2020.91885 |
| Makale Linki | https://jag.journalagent.com/ijmb/pdfs/IJMB-91885-ORIGINAL_INVESTIGATION-SEYDEL.pdf |
| Özet |
| Objectives: Glycated hemoglobin (HbA1c) is routinely utilized to monitor long-term glycemic control. The presenceof hemoglobin (Hb) variants may lead to a false HbA1c measurement. This study was an investigation of the effects ofboth common and rare Hb variants on the level of HbA1c measured with high-performance liquid chromatography(HPLC).Methods: : The HbA1c level of a total of 391 patients without Hb variants (HbAA, n=44) and with Hb variants (HbAS,HbSS, HbSS(A), HbSS(F), HbAD, HbAE, HbAF, HbD-Iran/D-Iran, HbD-Los Angeles/A, HbE-Saskatoon/E-Saskatoon, HbEE,HbG-Coushatta/A, HbOArab/OArab, HbSE, and Hb Stanleyville II, n=347) was measured using an HPLC analyzer.Results: The HbA1c level of all of the Hb variants but HbStanleyville II and HbG-Coushatta/A was extremely low. However, when the Hb variants were considered as a single group, a statistically significant difference was seen in comparison with the group that had no Hb variants (p<0.001).Conclusion: It was determined that the measurement of HbA1c can be adversely influenced by the presence of someHb variants. Hemoglobin variants should be investigated when the HbA1c level is incompatible with blood glucose. |
| Anahtar Kelimeler |
| HbA1c | hemoglobin variants | high-performance liquid chromatography |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 1 |
| TRDizin | 1 |
| Google Scholar | 2 |