The effect of atorvastatin on penile intracavernosal pressure and cavernosal morphology in normocholesterolemic rats
Yazarlar (6)
Sağlık Bilimleri Üniversitesi, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Prof. Dr. Fikret ERDEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Urology |
| Dergi ISSN | 2149-3235 |
| Dergi Tarandığı Indeksler | Emerging Sources Citation Index |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2019 |
| Cilt No | 45 |
| Sayı | 2 |
| Sayfalar | 91 / 96 |
| DOI Numarası | 10.5152/tud.2018.98048 |
| Makale Linki | https://turkishjournalofurology.com/en/the-effect-of-atorvastatin-on-penile-intracavernosal-pressure-and-cavernosal-morphology-in-normocholesterolemic-rats-1610332 |
| Özet |
| Objective: A debate is open on the effects of lipid-lowering drugs on sexual function. We aimed to investigate the effect of atorvastatin use on penile intracavernosal pressure (ICP) and cavernosal morphology.Material and methods: Fourteen mature male Sprague-Dawley-rats were randomly assigned to either thecontrol group (which received standard food and water ad libitum) or the atorvastatin group (which receivedstandard food, water, and statin) for twelwe weeks. At the end of the study, ICPs were measured with cavernosometry. Penectomy specimens were histologically examined.Results: The following mean values were obtained for the control and atorvastatin groups, respectively:pre-study body weights (350±16.9 g and 331.4±24.9 g); post-study body weights (356±18 g and 368±22.5 g(p>0.05); ICPs at 5 V (5.96±5.16 mmHg and 2.11±1.22 mmHg (p=0.07)); ICPs at 10 V (18.28±14.1 mmHgand 5.56±5.58 mmHg) (p=0.09); testosterone (1.23±0.78 and 0.78±0.58 mmol/dL) (p=0.39); blood glucose (151±22 mg/dL and 168.6±16.2 mg/dL) (p=0.12); triglyceride (93.4±19.8 mg/dL and 52.1±18.6 mg/dL) (p=0.01); total cholesterol (50.2±7.2 mg/dL and 47.7±6.6 mg/dL) (p=0.51); and low-density lipoprotein(LDL) cholesterol (10.0±4.4 mg/dL and 3.5±2.1 mg/dL) (p=0.01). The mean collagen thickness was similar(p=0.09); but the mean elastin thickness increased in the atorvastatin group (p=0.01).Conclusion: The present study showed that the use of atorvastatin reduced the intracavernosal pressure in10 V stimulation, and minimally decreased testosterone levels in rats, within a short period of time. Whenstatin treatment is considered for its protective properties on cardiovascular system or for its lipid-loweringeffect. It should be kept in mind that atorvastatin may also adversely contribute to erectile dysfunction. |
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BM Sürdürülebilir Kalkınma Amaçları
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