Effect of atorvastatin on spermatogenesis in rats: A stereological study
Yazarlar (8)
Ekrem Akdeniz
Mehmet Emin Önger
Mustafa Suat Bolat
Prof. Dr. Fatih FIRAT Türkiye
Metin Gür
Mustafa Bakırtaş
Abdullah Açıkgöz Türkiye
Prof. Dr. Fikret ERDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Tropical Journal of Pharmaceutical Research (Q4) | ||
| Dergi ISSN | 1596-5996 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 15-03-2021 |
| Cilt / Sayı / Sayfa | 19 / 12 / 2609–2614 | DOI | 10.4314/tjpr.v19i12.19 |
| Makale Linki | https://www.ajol.info/index.php/tjpr/article/download/204690/193009 | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| Purpose: To investigate the effects of oral atorvastatin on spermatogenesis in a rat model.Methods: Rats were equally assigned into control and study groups, the latter receiving atorvastatin (20 mg/kg/day). At the end of 12 weeks, spermatogenetic activity was evaluated using stereological and optical fractionator methods. Serum follicle-stimulating hormone (FSH), total testosterone (TT), and luteinizing hormone (LH) levels were measured using micro–ELISA kits. Total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL - C), and high-density lipoprotein cholesterol levels were also measured by enzymatic colorimetric assays.Results: Testicular stereological analysis revealed that atorvastatin reduced Sertoli cell numbers (p < 0.001), spermatogonia (p < 0.001), spermatocytes (p < 0.001), and seminiferous tubule diameters (p < 0.001). LDL – C (p = 0.01) and TG (p = 0.01) values were significantly lower in the study group compared with the control group. There was no significant difference in FSH (p = 0.44), LH (p = 0.48),and TT (p = 0.06) levels between the groups.Conclusion: The findings show that atorvastatin causes deleterious effects on rat spermatogenesis. It should therefore be used with caution in clinical practice owing to its potential adverse effects, especially on male fertility. Keywords: Statin, Atorvastatin, Spermatogenesis, Stereology, Testis |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |