Ondansetron and AS19 attenuate morphine tolerance by modulating serotonin 5-HT3 and 5-HT7 receptor expressions in rat dorsal root ganglia
Yazarlar (5)
Doç. Dr. Şeyma ÖZSOY
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sivas Cumhuriyet Üniversitesi, Türkiye
Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Radiation Research and Applied Sciences |
| Dergi ISSN | 1687-8507 Wos Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2023 |
| Cilt No | 16 |
| Sayı | 100682 |
| DOI Numarası | 10.1016/j.jrras.2023.100682 |
| Makale Linki | http://dx.doi.org/10.1016/j.jrras.2023.100682 |
| Özet |
| Opioid drugs are frequently preferred drugs for severe pain, but their long-term use causes tolerance to their analgesic effects. However, the factors that contribute to the development of tolerance to opioids are diverse and not fully understood. In this study, our aim was to investigate the effects of 5-HT 3 receptor antagonist ondansetron (ODN) and 5-HT 7 receptor agonist AS19 on morphine analgesia and tolerance in rats. Randomly selected Wistar Albino (230-260 g) 90 male rats were included in the study. To develop morphine tolerance, high-dose (50 mg/kg) of morphine was administered subcutaneously daily for three days, and tolerance was evaluated at 30-min intervals for 120 min by thermal analgesia tests on the 4th day. After thermal analgesia measurements, dorsal root ganglia (DRGs) at spinal L 4-S 5 level were isolated. 5-HT 3 and 5-HT 7 receptor protein expressions in DRGs were measured by immunohistochemical method. Study results show that co-administration of ODN or AS19 with morphine indicated a significant increase in analgesic effect compared to morphine alone. In addition, a significant reduction in morphine tolerance was observed when ODN or AS19 was administered with morphine. H-score analysis significantly increased 5-HT 3 receptor expressions in the morphine-tolerant rats, and administration of ODN prevented this. Similarly, 5-HT 7 receptor expression was significantly decreased in the morphine tolerant group, and the administration of AS19 increased this expression. In conclusion, these study results suggest that both ODN and AS19 alter the 5-HT 3 and 5-HT 7 receptor expressions in the DRG and … |
| Anahtar Kelimeler |
| 5-HT receptors | Ondansetron | AS19 | Dorsal root ganglia | Morphine tolerance |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 4 |
| Google Scholar | 5 |