Detection of nuclear receptors in gingival samples of diabetic and nondiabetic periodontitis patients
Yazarlar (6)
Doç. Dr. Özkan KARATAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hatice BALCI YÜCE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Mehmet Murat TAŞKAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Necmettin Erbakan Üniversitesi, Türkiye
Prof. Dr. Ercan ÇAÇAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Nigerian Journal of Clinical Practice |
| Dergi ISSN | 1119-3077 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2021 |
| Cilt No | 24 |
| Sayı | 2 |
| Sayfalar | 269 / 276 |
| DOI Numarası | 10.4103/njcp.njcp_216_20 |
| Makale Linki | https://www.njcponline.com/text.asp?2021/24/2/269/309811 |
| Özet |
| Diabetes and periodontitis are two chronic inflammatory diseases sharing specific etiopathogenetic mechanisms, and both cause severe inflammation and destruction. The present study aimed to determine the receptor expressions of peroxisome proliferative-activated receptor (PPAR)-γ, retinoid X receptor (RXR)-α, vitamin D receptor (VDR), and nuclear factor kappa B (NF-κB) expressions in healthy gingiva and diseased gingival samples with or without diabetes. Forty-five participants as (1) healthy controls (C), (2) periodontitis group (P), and (3) diabetes and periodontitis group (DP) were enrolled. Plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment levels (CAL), and bleeding on probing (BOP) were recorded in all participants. Two gingival biopsies from each participant were obtained, and one underwent histological tissue processing while the other underwent qRT-PCR analysis of nuclear receptors. Inflammatory and fibroblast cell counts, PPAR-γ, RXR-α, VDR, and NF-κB were evaluated. Fibroblast cells were lowest in the DP group and highest in the healthy group. PPAR-γ, VDR, RXR, and NF-κB expressions were higher in the healthy controls in the qRT-PCR analysis and similar in the other groups. Immunohistochemistry analysis also showed similar results. qRT-PCR results concluded that healthy gingival samples had higher PPAR-γ, RXR, VDR, and NF-κB expressions, and immunohistochemistry findings supported the results. In addition, healthy gingiva contained higher fibroblast cells and lower inflammatory cells. |
| Anahtar Kelimeler |
| Diabetes | NF-κ | B | PPAR-γ | periodontitis | RXR | VDR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 4 |
| Google Scholar | 7 |