PPAR‑γ, RXR, VDR, and COX‑2 Expressions in Gingival TissueSamples of Healthy Individuals, Periodontitis and Peri-ImplantitisPatients
Yazarlar (2)
Doç. Dr. Mehmet Murat TAŞKAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Niger J Clin |
| Dergi ISSN | 1119-3077 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 23 |
| Sayı | 1 |
| Sayfalar | 46 / 53 |
| DOI Numarası | 10.4103/njcp.njcp_349_19 |
| Makale Linki | www.njcponline.com |
| Özet |
| Periodontitis and peri-implantitis are irreversible destructive diseases of periodontal and peri-implant tissues. This study aimed to determine the receptor expressions of peroxisome proliferative-activated receptor (PPAR)-γ, retinoid X receptor (RXR)-α, vitamin D receptor (VDR), and cyclooxygenase (COX)-2 in diseased tissues around teeth and dental implants. The study consisted of three groups: group 1, healthy group (C, n = 15); group 2, periodontitis patients with stage 3 grade B (P, n = 15); and group 3, peri-implantitis patients (PI, n = 15). Periodontal clinical parameters such as the plaque index (PI), gingival index (GI), and probing pocket depths (PPD) were recorded. Gingival and peri-implant mucosal biopsies were obtained from all participants and biopsy samples underwent histological tissue processing. Hematoxylin-eosin (H & E) and immunohistochemistry staining were performed. Total inflammatory cell counts and fibroblast cell density were evaluated on H and E-stained slides, while PPAR-γ, RXR-α, VDR, and COX-2 were evaluated through immunohistochemistry. The age of participants were similar, while PI, GI, and PPD values were higher in periodontitis and peri-implantitis groups compared with healthy group. Inflammatory cell infiltration was higher in periodontitis and peri-implantitis compared with healthy group, while fibroblast cell density exhibited a reverse pattern. PPAR-γ and also COX-2 expressions were lower in the healthy group and higher in periodontitis and peri-implantitis groups. RXR-α and VDR were higher in the healthy group and lower in the periodontitis and peri-implantitis groups. The results revealed that RXR-α and VDR levels were higher, while PPAR-γ and COX-2 levels were lower in the healthy group and periodontitis and peri-implantitis groups resulting in similar expressions in the tested parameters. |
| Anahtar Kelimeler |
| COX-2 | peri-implantitis | periodontitis | PPAR-gamma | RXR | VDR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 22 |
| Google Scholar | 30 |