Hyaluronic acid with antioxidants improve wound healing in rats
Yazarlar (7)
Doç. Dr. Mehmet Murat TAŞKAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hatice BALCI YÜCE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Özkan KARATAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gözde IŞIKER KARA
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY |
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2021 |
| Cilt No | 96 |
| Sayı | 7 |
| Sayfalar | 536 / 545 |
| DOI Numarası | 10.1080/10520295.2020.1832255 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2020.1832255 |
| Özet |
| Hyaluronic acid (HA) is found in connective tissue and participates in wound healing. We investigated the efficacy of a HA gel (2% hyaluronic acid; 1% antioxidants, coenzyme Q10 and vitamin E; and 5% benzocaine) on healing of palatal wounds in rats. We established two groups of rats: a control group treated with vehicle and an HA group treated with HA gel. The control group was divided into five subgroups and the HA group was divided into four subgroups according to the day on which animals were sacrificed. Wounds were created by elevating 5 mm diameter full thickness flaps. Healed and unhealed wound areas were measured using photographs. Transforming growth factor (TGF)-β, insulin-like growth factor (IGF), and collagen I and III expressions were determined using immunohistochemistry. The number of fibroblasts increased and inflammatory cells decreased from day 0 to 21 in both groups. The HA group exhibited more fibroblasts by day 7 compared to controls; (TGF)-β and IGF levels were similar between HA and control groups. HA groups exhibited fewer inflammatory cells than controls on days 3 and 7. We found significant differences in TGF-β and IGF levels among HA groups between days 3 and 21, and among control groups between days 0 and 21. Collagen I and III levels were greater for the day 3 HA group compared to controls. We observed improved wound healing in HA treated rats within 7 days. |
| Anahtar Kelimeler |
| Antioxidants | coenzyme Q10 | hyaluronic acid | palate | rats | vitamin E | wound healing |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 21 |
| Google Scholar | 37 |