3,4,5-Trihydroxybenzoic Acid Attenuates Ligature-Induced Periodontal Disease in Wistar Rats
Yazarlar (2)
Doç. Dr. Özkan KARATAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry |
| Dergi ISSN | 1871-5230 Scopus Dergi |
| Dergi Tarandığı Indeksler | MEDLINE/PubMed |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 20 |
| Sayı | 1 |
| Sayfalar | 51 / 60 |
| DOI Numarası | 10.2174/1871523019666200206094335 |
| Makale Linki | http://dx.doi.org/10.2174/1871523019666200206094335 |
| Özet |
| Background 3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an antiinflammatory agent that could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined. Methods Thirty-two Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation … |
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| Google Scholar | 8 |