Quercetin decreased alveolar bone loss and apoptosis in experimentally induced periodontitis model in Wistar rats
Yazarlar (2)
Doç. Dr. Mehmet Murat TAŞKAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | Anti-Inflammatory Anti-Allergy Agents in Medicinal Chemistry |
| Dergi ISSN | 1871-5230 Scopus Dergi |
| Dergi Tarandığı Indeksler | MEDLINE/PubMed BIOSIS Previews BIOSIS Reviews Reports and Meetings Scopus EMBASE/Excerpta Medica Chemical Abstracts Service/SciFinder ProQuest ChemWeb Google Scholar PubsHub MediaFinder®-Standard Periodical Directory Genamics JournalSeek J-Gate CNKI Scholar Suweco CZ TOC Premier EBSCO British Library Ulrich's Periodicals Directory JournalTOCs QOAM |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 19 |
| Sayı | 4 |
| Sayfalar | 436 / 448 |
| Makale Linki | http://www.eurekaselect.com/178602/article |
| Özet |
| Background Quercetin is a flavonoid which has potent anti-inflammatory, antibacterial, and antioxidant effect. Purpose of this study was to evaluate effects of quercetin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats. Methods Wistar rats were divided into four experimental groups: non-ligated control (C, n=8) group; periodontitis (P, n=8) group; ligature and low dose quercetin group (75 mg/kg/day quercetin, Q75 group, n=8); ligature and high dose quercetin group (150 mg/kg/day quercetin, Q150 group, n=8). Silk ligatures were placed at gingival margin of lower first molars of mandibular right quadrant. Study duration was 15 days, and animals were sacrificed end of this period. Changes in alveolar bone levels were clinically measured and tissues were immunohistochemically examined, matrix metalloproteinase 8 (MMP 8), inducible nitric oxide synthase (iNOS), tissue … |
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