Effects of low-dose oxcarbazepine administration on developing cerebellum in newborn rat: A stereological study
Yazarlar (10)
Karadeniz Teknik Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Ordu Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Düzce Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Neuroscience Research Communications |
| Dergi ISSN | 0893-6609 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2004 |
| Cilt No | 34 |
| Sayı | 1 |
| Sayfalar | 28 / 36 |
| DOI Numarası | 10.1002/nrc.10103 |
| Makale Linki | http://doi.wiley.com/10.1002/nrc.10103 |
| Özet |
| Oxcarbazepine (OXC) is a widely used novel antiepileptic drug that has been available for routine prescription for 10 years. To examine low dose OXC‐induced neurotoxic effects on cerebellar development, we administered 25 mg/kg OXC orally to newborn Wistar rats once a day on postnatal days 2–14. Microscopic processed cerebellar sections of the control and treated groups were examined by volumetric analysis. Volume estimations were obtained using the Cavalieri's principle using a computerized stereological image analyzer (CAST‐GRID). The total volume of the cerebellum, white matter and the various cerebellar layers (except extragranular layer) were significantly increased in the treated animals. These data may provide useful implications for the management of OXC‐induced developmental neurotoxicity in children exposed to OXC during the late fetal period. Our findings suggest that women … |
| Anahtar Kelimeler |
| oxcarbazepine | Cavalieri principle | cerebellum | volume measurements | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 23 |
| Google Scholar | 34 |